Brain Tumor Pharmacogenomics and Brain-Machine Interfaces

I am currently a 6th year MD-PhD student at Yale where I am pursuing a PhD in Genetics under the mentorship of Dr. Murat Gunel. I am undertaking a genomics-based approach to elucidate the influence of receptor signaling networks in meningioma biology in the context of the recent clinical observation of differential response of meningioma mutation subgroups to endocrine-based therapeutics using a combination of machine learning approaches and applying ecological and evolutionary theory to single-cell and spatial-level transcriptomics and epigenomics.

My long-term goal is to pursue a career as a neurosurgeon-scientist specializing in brain tumors and functional restoration via brain-machine interfaces. Scientifically, I intend to utilize genomics and epigenomics to establish how transcription factors are regulated in response to various pharmacological therapies, with the goal of understanding treatment-refractile brain tumors and strategizing new interventions. Additionally, I have a deep interest in the development and understanding of how to integrate cell-signaling mechanics into biologically meaningful input for the development of new brain-machine interfaces.